Afamin may also play a role in the Wnt signalling pathway or serve as a chaperone enhancing the solubility of Wnt proteins (Mihara et al., 2016 ▸) and has a potential role in glucose metabolism in papillary thyroid carcinoma (Shen et al., 2016 ▸). Here, AFM is linked to thyroid gland papillary carcinoma.