During the infection process of invasive S. aureus, pathogen-associated-molecules initiate the innate immune system leading to activation and recruitment of neutrophils and macrophages and the production of pro-inflammatory cytokines, most notably TNF-α, IL-1β, and IL-6 (Bekeredjian-Ding et al., 2015; Giai et al., 2016; Zhao et al., 2016). The gene discussed is TNF; the disease is infection.