In our study, two organophosphate insecticides, terbufos and fonofos, were associated with an increased risk of prostate cancer among those carrying one or two copies of the variant allele in HSD17B4 (rs7723390), which showed a low correlation with rs384346, and no association among men carrying two copies of the wild-type allele. Here, HSD17B4 is linked to Familial prostate cancer.