ACAN and Lhermitte-Duclos disease: LDD is characterized by progressive loss of aggrecan (Le Maitre et al. 2009), annular fibrosis rupture (Kazezian et al. 2015; Pirvu et al. 2015), collagen type transformation, cartilage endplate alterations (Arpinar et al. 2015) and decreased disc height (Jarman et al. 2015).