NOTCH2 and leukemia: To further elucidate the molecular mechanism by which miR-150 regulates the proliferation of LSCs (Figure 4A), we tested the expression levels of genes including Notch2, Hsp90B1, and CTNNB1, besides Nanog (Zbinden et al., 2010; Liu et al., 2015; Zhu et al., 2015; White et al., 2016), which are known oncogenic and stem cell regulators that are implicated in leukemia initiation and progression.