Moreover, we have previously shown that liraglutide reduces reactive oxygen species after traumatic brain injury, preserves mitochondrial function, and is associated with increasing the CREB-regulated, antioxidants: peroxisome proliferator-activated receptor-gamma coactivator-1 alpha and neuroglobin (DellaValle et al., 2014). The gene discussed is PPARGC1A; the disease is brain injury.