Of these two MSA models, one was a comparative study of frontal cortex from several neurodegenerative transgenic mice models: (i) two different models of MSA in which α-synuclein was expressed under the control of oligodendrocyte-specific MPG promoter (lines MBP1- hαsyn and MBP29-hαsyn, medium and high αsyn expression respectively); (ii) DLB/PD; (iii) AD; and (iv) tauopathy (Ubhi et al., 2014). This evidence concerns the gene SNCA and multiple system atrophy.