The fact that miR-133b was previously shown to promote neurite outgrowth and enhance neural function recovery after spinal cord injury and stroke by targeting RhoA (Liu et al., 2009; Yu et al., 2011; Xin et al., 2013), prompted Niu et al. (2016) to investigate the potential neuroprotective effect of miR-133b in the MPP+ model. This evidence concerns the gene RHOA and stroke disorder.