Genetic investigations, conducted with adult patients with Lyme-caused arthritis, showed that molecules of the major histocompatibility complex (MHC) class II—DR2 and DR4, as well the association with anti-OspA-antibodies suggest a chronic course of arthritis and facilitate antibacterial therapy of low efficacy [34,35,36,37,38,39]. This evidence concerns the gene TNFRSF10A and Arthritis.