Capsaicin is a capsaicinoid that causes a cutaneous neurogenic inflammation after activation of the vanilloid receptor subtype 1 (TRPV1) with generation of substance P (SP) and calcitonin gene related peptide (CGRP) and release of proinflammatory mediators, such as BK, histamine, 5-HT, and PG [47,48]. The gene discussed is TAC1; the disease is inflammatory response.