However, it has to be stressed here that an infection with a liver-tropic virus was needed to generate a fertile field for the chronic autoimmune destruction to be initiated and/or propagated, since subcutaneous injection of recombinant CYP2D6 and complete Freund’s adjuvant also results in the generation of CYP2D6-specific B and T cells but was not sufficient to cause liver damage and AIH [47]. This evidence concerns the gene CYP2D6 and autoimmune hepatitis.