ACHE and Huntington disease: Thus, AChE and BuChE, present at high levels in MS patients, alter the steady-state equilibrium of ACh and the ratio of AChE and BuChE to ACh was higher in MS patients than in HD (AChE/ACh 3.6 vs. 0.7, p < 0.001, and BuChE/ACh 13.0 vs. 3.1, p < 0.001).