Given the crucial role of PAR2 in the TGF-β control of cell motility, it is conceivable that PAR2 also impacts TGF-β-induced EMT as well as EMT-associated changes, such as adoption of a spindle-shaped morphology, proliferation arrest, autoinduction of TGF-β1 ligand, chemoresistance and cancer stem cell (CSC) formation. This evidence concerns the gene F2RL1 and cancer.