LARGE1 and hereditary disease: These genetic diseases are often caused by mutations in genes encoding glycosyltransferases (or putative glycosyltransferases) such as POMT1 and POMT2 (encoding protein O-mannosyltransferases 1 and 2, respectively) [1,2,3]; POMGnT1 (encoding protein O-mannose N-acetylglucosaminyl transferase 1) [4]; LARGE (encoding like-glycosyltransferase) [5]; and others including fukutin and fukutin-related protein (FKRP) [6,7,8,9,10,11,12,13,14].