For example, fluconazole itself is not metabolized by UGT but alter pharmacokinetic parameters of co-administrated zidovudine in AIDS patients, because the glucuronidation of zidovudine by UGT2B7 is strongly inhibited by fluconazole [12]; indinavir [13] and sorafenib [14] can disturb the activity of UGT1A1, resulting in the inhibition of bilirubin gulucuronidation; atractylenolide I and III have been proven to specifically inhibit UGT2B7, thus affecting drugs undergoing UGT2B7- catalyzed metabolism [15]. This evidence concerns the gene UGT2B7 and AIDS.