In this prospect, the transcriptional regulation of GD3S gene (ST8SIA1), the key enzyme involved in the biosynthesis of b-and c-series gangliosides, has been well described in melanoma, neuroblastoma and breast cancer cells; highlighting a crucial role of NF-κB in activating this gene [103,104,105]. This evidence concerns the gene NFKB1 and breast carcinoma.