FN1 and liver dysplastic nodule: In the glomerulus, where mesangial cells constitute 30% of all glomerular cells (Schlondorff, 1987), DN is characterized by mesangial cell hypertrophy, proliferation, and an increase in production of mesangial matrix (e. g.: type IV collagen, laminin and fibronectin) (Stratman, Malotte, Mahan, Davis, and Davis, 2009).