MAPT and tauopathy: Based on the morphology and distribution of the predominant species of tau deposited, FTLD-tau cases are subclassified into 3R (i.e. Pick’s disease) and 4R tauopathies (i.e. corticobasal degeneration, progressive supranuclear palsy and, more recently, globular glial tauopathy) [68, 69].