Since Gpr151: (a) expression is markedly increased in the DRG after models of neuropathic pain; (b) is expressed in the habenula which is modulated by nociceptive stimulation; and (c) is homologous to the galanin receptors which are known to modulate nociception (reviewed in (Lang et al., 2015)), we compared thermal and mechanical nociceptive responses in intact Gpr151 MUT and WT mice and then in models of inflammatory and neuropathic pain. Here, GPR151 is linked to Pain.