To test this, we examined the expression of RAPTOR, phosphorylated AKT, and filaggrin in the unaffected, nonlesional, nonflexural epidermis of 5 patients with early-onset severe AD and of 3 subjects without AD (Fig 1, A and B, and Table E1 in this article's Online Repository at www.jacionline.org). Here, FLG is linked to Alzheimer disease.