Although there has been a great deal of study of FLG mutations and their association with barrier disruption and AD, there are surprisingly few reports on variation of filaggrin protein levels and filaggrin processing.37, 38, 39 Here we show that the increase in RAPTOR expression correlates with the decrease in filaggrin expression and processing not only in patients with AD but also in healthy “unaffected” subjects. This evidence concerns the gene RPTOR and Alzheimer disease.