Because inhibition of the mTORC1 complex by rapamycin increases AKT1 phosphorylation in keratinocytes,18 we hypothesized that the inverse could occur and that increased expression of the key mTORC1 protein RAPTOR in patients with AD would result in a reduction of AKT1 phosphorylation and therefore activity. This evidence concerns the gene AKT1 and Alzheimer disease.