In a study of the then 31 identified RA risk loci, only one SNP (rs10919563) on PTPRC/CD45 was associated with European League Against Rheumatism (EULAR) response and DAS28 changes among TNFi starters, with reasonable replications and acceptable sample sizes (ca. 1200 in each study) [25, 26]. The gene discussed is PTPRC; the disease is rheumatoid arthritis.