In addition, none of the haplotypes, either based on four amino acids (11/13/71/74) or on three amino acids (11/71/74, 11 and 13 are in high LD), were significantly associated with good/moderate EULAR response in RA overall or ACPA-positive RA, except for a few suggestive significances in ACPA-negative RA (Table 4). This evidence concerns the gene PRTN3 and rheumatoid arthritis.