PRTN3 and rheumatoid arthritis: As shown in Table 5 and Additional file 13: Table S12, the only consistent association with nominal significance lay in ΔHAQ in ACPA-positive RA, where the GRS together with SE explained approximately 5% of variance (range: 3.4–5.4%), although this significance would not withstand correction for the number of tests (eight tests performed per amino acid position).