Our results for treatment response, however, did not immediately support the finding that the valine-containing VKA haplotype was associated with a good EULAR response (OR in [24] = 1.23 (1.06–1.43)), while the OR was 1.06 (0.58–1.94) for our data among ACPA-positive RA patients. This evidence concerns the gene PRTN3 and rheumatoid arthritis.