PDCD1 and neoplasm: Even though stratified analysis according to levels of lymphocytic infiltration was not performed due to the low number of cases in each subgroup, our results suggest that the presence of PD-1+ and LAG-3+ TILs in the tumor microenvironment may reflect the occurrence of an active, although partially exhausted, intratumoral immune response, rather than representing a global marker of immunosuppression.