The IHC staining results of E-cadherin and Vimentin in tumor xenografts formed by injecting SW480-SHB, SW480-sh-LCN2, SW620-OB and SW620-LCN2 cells subcutaneously showed that E-cadherin expression was reduced in LCN2-knockdown but increased in LCN2-overexpression mouse xenograft tissue compared to the corresponding control xenograft tissue. The gene discussed is SHB; the disease is neoplasm.