Next, to investigate the relationship between LCN2/NF-κBp65 expression and the prognosis of CRC patients, we divided the clinical samples into four groups according to LCN2 and nuclear NF-κBp65 expression: 1: LCN2 (+)/NF-κBp65 (−), n = 21, 3 died; 2: LCN2 (−)/NF-κBp65 (−), n = 48, 17died; 3: LCN2 (+)/NF-κBp65 (+), n = 27, 10 died; 4: LCN2 (−)/NF-κBp65 (+), n = 30, 13 died (follow-up time, 1–200 months; median, 52 months). Here, LCN2 is linked to colorectal carcinoma.