CD4 and myeloid sarcoma: Although both IL-7Rα [16–21] and the inhibitory receptor PD-1 [22–24] have been implicated in MS/EAE pathogenesis, it is not clear whether the key cytokines and/or transcription factors that are critical for T cell encephalitogenicity regulate IL-7Rα/PD-1 balance of myelin-specific CD4 T effector/memory cells during EAE development.