EGFR and non-small cell lung carcinoma: Additionally, the TIGER-3 study (ClinicalTrials.gov, NCT02322281) is a phase III study that seeks to compare rociletinib with single-agent cytotoxic chemotherapy as a third-line or later treatment for advanced EGFR mutation-positive NSCLC in patients for whom EGFR-TKI and platinum-doublet therapy have failed.