Recently, it has been proven that several transcription regulators such as nuclear factor‐κB (NF‐κB), GATA transcription factors, nuclear factor of activated T cells, myocardium‐related factor A, and myocyte enhancer factor‐2 were activated in development of cardiac hypertrophy, which could induce the expression of hypertrophic genes promoting pathological cardiac hypertrophy.2, 4, 5, 6, 7, 8, 9, 10 Although numerous studies of cardiac hypertrophy have been reported, the molecular mechanisms of cardiac hypertrophy remain to be elucidated. The gene discussed is NFKB1; the disease is cardiac hypertrophy.