To further explore the relationship of the NF‐κB p65 pathway and SNIP1 in AB‐induced cardiac hypertrophy, we crossed the cardiomyocyte‐restricted overexpression of phosphorylation‐resistant IκBα (IκBαS32A/S36A) mice with SNIP1‐KO mice to generate IκBα (IκBαS32A/S36A)‐TG/SNIP1‐KO mice. This evidence concerns the gene RELA and cardiac hypertrophy.