In our present studies, the cardiac hypertrophy induced by AB operation was followed by the activation of NF‐κB signaling pathway (increased phosphorylation of NF‐κB p65, IKKβ, and IκBα), and this activation was significantly upregulated in the hearts of SNIP1‐KO mice and downregulated in TG mice hearts (Figure 7A). The gene discussed is IKBKB; the disease is cardiac hypertrophy.