It is well known that NF‐κB signaling is indispensable for the regulation of various cardiovascular diseases, especially for cardiac hypertrophy, fibrosis, and ventricular remodeling.11, 12, 18, 19, 20, 21, 22 Nevertheless, the role of NF‐κB signaling in the regulation of cardiac hypertrophy remains controversial. The gene discussed is NFKB1; the disease is cardiovascular disorder.