It is well known that NF‐κB signaling is indispensable for the regulation of various cardiovascular diseases, especially for cardiac hypertrophy, fibrosis, and ventricular remodeling.11, 12, 18, 19, 20, 21, 22 Nevertheless, the role of NF‐κB signaling in the regulation of cardiac hypertrophy remains controversial. This evidence concerns the gene NFKB1 and cardiac hypertrophy.