A similar observation, also emphasising the importance of the intracellular cortactin localisation, has been made in human fibrosarcoma cells, where the total amount of cortactin was unchanged by treatment with alpha-tocopheryl phosphate, whereas a delocalisation of cortactin from cell membrane and invadopodia to the cytoplasm occurred accompanied by reduced cell motility [58]. This evidence concerns the gene CTTN and fibrosarcoma.