Temporal blockage of Nrf2-dependent cytoprotection using Nrf2 inhibitors is important to enhance a patient's response to chemo- and radiotherapy but on the other hand, activation of Nrf2 pathway supports treatment of neurodegenerative diseases, multiple sclerosis and prevents cancer initiation by counteracting oxidative and electrophilic stress [60]. The gene discussed is NFE2L2; the disease is multiple sclerosis.