Attenuates TrxR by alkylation of C-terminal redox-active site Ser498; inhibits Trx/TrxR expression facilitating ROS accumulation in human cervical cancer cells [179]Suppresses TNF-α-mediated activation of NFκB in CML cells and AML leukemia cells[180]. The gene discussed is TXN; the disease is acute myeloid leukemia.