Ki-67 staining of the tumor sections (Figure 6D) showed that tumors in Mia-S3E group had higher Ki-67 expression levels compared to tumors in Mia-VCtrl group (Figure 6E), indicating that there was greater cell proliferation in Sema3E-overexpressing tumors compared to the controls, which could explain why Mia-S3E tumors had greater overall tumor mass. Here, MKI67 is linked to neoplasm.