Genomic analyses of large cohorts of human PDAC samples have uncovered genetic aberrations in axon guidance genes, specifically SEMA3E gene which was found to be aberrantly amplified (copy number variations, CNV) in the majority of the samples [9–11]; Therefore, the significance of amplified Sema3E gene in pancreatic cancer warrants further study. This evidence concerns the gene SEMA3E and pancreatic neoplasm.