As shown in Figure 3A, immunoblot analysis of Sema3E protein expression in five PDAC cell lines as well as the transformed human pancreatic ductal epithelium (HPDE) cells serving as a non-tumor control cell line, revealed moderate to high expression of the 87 kDa full-length form of Sema3E protein in all five cancer cell lines, but not in the HPDE control cells. Here, SEMA3E is linked to neoplasm.