Nevertheless, over-expression of PKM2 in gastric cancer (3 studies, pooled HR = 1.19, 95%CI = 0.84-1.68, P = 0.332, I2 = 47.4%) and pancreatic cancer (4 studies, pooled HR = 1.41, 95%CI = 0.68-2.93, P = 0.355, I2 = 81.3%) has no effect on OS, along with a moderate heterogeneity observed in pancreatic cancer (Figure 3). Here, PKM is linked to familial pancreatic carcinoma.