The consequences of p53 mutations (gain-of-function, GOF) within a cell can have at least three types of outcomes [3–6]: 1) p53 mutations can abrogate the tumor suppressor function of the affected TP53 allele by reducing the overall capacity of the cell to mount a proper DNA damage response [6, 7], 2) the mutant p53 may exert dominant–negative effect over co-expressed wild type p53 by forming mixed tetramers that are incapable of DNA binding and transactivation [6, 8] and 3) the mutant p53 protein with activities of its own, can contribute to various aspects of tumor progression [6, 9, 10]. The gene discussed is TP53; the disease is neoplasm.