Although XIST expression was not associated with parameters such as age (P = 0.175), gender (P = 0.651), Lauren histotype (P = 0.934) and Helicobacter pylori infection (P = 0.573), high XIST expression was significantly correlated with tumor size (P = 0.006), lymph node metastasis (P = 0.002) and late clinical stage (P = 0.005). The gene discussed is XIST; the disease is metastatic malignant neoplasm in the lymph nodes.