ETHE1 and ethylmalonic encephalopathy: Hepatotropic AAV2/8 serotype was successfully used to express the wild-type form of mitochondrial sulfide di-oxygenase Ethe1 in the liver of Ethe1−/− mice, a model of ethylmalonic encephalopathy (EE), a highly severe mitochondrial disease due to impaired disposal of toxic hydrogen sulfide (H2S) and a poison for cytochrome c oxidase [34].