In addition to colon cancer, PRL-3 was also found to be overexpressed in many other human cancer types, such as Hodgkin's lymphoma [5], melanomas [6], acute myeloid leukemia (AML) [7], gastric [8], ovarian [9], breast [10], and esophageal squamous cell carcinoma [11]. This evidence concerns the gene PTP4A3 and malignant colon neoplasm.