[29,30] In addition, miR-29 family members (which downregulate the DNA methyltransferases DNMT3A and DNMT3B), as well as demethylation agents decreased promoter methylation and increased expression of WIF-1, as a result, those agents suppressed tumor proliferation and induced apoptosis in lung cancer cell lines. The gene discussed is DNMT3A; the disease is lung carcinoma.