The silencing of other antagonists (such as sFRPs, Cerberus, Dab2 and Dkk ) could affect prognosis on patients with NSCLC concomitantly by the hypermethylation of WIF1. A further multivariate analysis involving Wif-1, sFRPs, Cerberus, Dab2 and Dkk are required to find out whether Wif-1 methylation is independently or concomitantly associated with the prognosis in patients with NSCLC. This evidence concerns the gene WIF1 and non-small cell lung carcinoma.