SAHA or/and MG132 induced apoptosis in the glioma cells was attributable to the down-regulation of Bcl-2 protein levels and the up-regulation of 14-3-3, Bax, Caspase 9, Capase 3 expression via extrinsic and intrinsic pathways [28, 29]. This evidence concerns the gene CASP9 and central nervous system cancer.