UNC5B and Premature aging appearance-developmental delay-cardiac arrhythmia syndrome: Collectively, we reveal NTN1 and its re ceptor UNC5B as Naa10’s downstream targets, and their negative regulation may involves in regulation of both vasculogenesis and cell growth, the multifunction of Naa10 can help us better explain the variety of clinical manifestations and early death of Naa10 gene mutation induced Ogden Syndrome.