We examined the ability of endothelial PGC-1α expression to prevent ATII - induced hypertension in a prospective study where the WT and PGC-1α EC TG cohorts were administered LNAME (0.5 g/L) in the drinking water for 7 days followed by 7 days of LNAME + ATII. The gene discussed is PPARGC1A; the disease is hypertensive disorder.