We additionally testedthe usability of this reporter system for two additional disease-related genomic loci: the V30M mutation of the TTR gene which is well documented for familial amyloid polyneuropathy (FAP) and the D90A and R115G mutations in the SOD1 gene which are associated with amyotrophic lateral sclerosis (ALS). The gene discussed is SOD1; the disease is familial amyloid neuropathy.