In our study, the corresponding canonical cancer pathways in the HBL tumor transcriptome are GBM, Her-2 breast cancer, EGF and ERBB signaling (EGFR), Wnt-β-catenin signaling (Wnt), STAT3 and JAK/STAT signaling (JAK/STAT), and mTOR signaling pathways (mTOR, Supplementary Table S2). The gene discussed is EGF; the disease is breast cancer.