Since PGE2 levels were enhanced in the MSC secretome upon treatment with IFNγ, (Supplementary Figure 4) and PGE2 signaling has been shown to influence metabolic programs at the tumor cell-stromal interface49 we explored the relevance of COX2-generated PGE2 from MSCs in directing M1 to M2 bio-energetic shifts taking lessons from the tumor microenvironment. The gene discussed is IFNG; the disease is neoplasm.