As shown in Fig. 7a,b (also Supplementary Fig. S3), Akt phosphorylation was significantly decreased after treatment with conditioned media from LPS-stimulated BV2 microglia, and SCH treatment significantly increased Akt phosphorylation in a dose-dependent manner in cultured PC12 cells, with no change in total Akt levels. Here, AKT1 is linked to spindle cell hemangioma.