Importantly, individual silencing of CACNA1D or CACNA1S gene expression using multiple siRNA oligos (Supplementary Fig. 6A,B) decreased both filopodia formation and cancer cell invasion (Fig. 3b,c), indicating that CACNA1D and CACNA1S are likely to synergistically support filopodia formation and cancer cell invasion in MDA-MB-231 cells. This evidence concerns the gene CACNA1S and cancer.