In contrast to these observations, elevated expression of IL-25 receptor IL-17RB was shown to have a strong correlation with poor prognosis in breast cancer patients and a strong pro-tumor activity in breast tumor models, through regulating NF-κB-mediated anti-apoptotic pathway (Huang et al., 2014), or inflammatory chemokine expression, including CCL20/CXCL1/IL-8/TFF1 (Wu et al., 2015). This evidence concerns the gene IL17RB and breast cancer.