The Fanconi anemia pathway may mediate HR repair of DPCs in higher eukaryotes (Stingele and Jentsch, 2015); Ren et al. (2013) has illustrated human lymphoblasts deficient in FANCD2, a homologous repair gene involved in DNA crosslink repair via the Fanconi anemia pathway, were more susceptible to FA, with DPCs increasing in a dose-dependent manner. The gene discussed is FANCD2; the disease is Fanconi anemia.