Nonetheless, studies of ex vivo patient tissues using higher resolution immuno-gold labeling and electron microscopy did uncover solid evidence for amyloid-like fibrils formed by TDP-43 in ALS/FTLD affected neurons (Thorpe et al., 2008) as well as cells affected by other neurodegenerative diseases (Lin and Dickson, 2008). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.