There were significant differences in levels of MMP-1, MMP-2, TIMP-1, TIMP-2, TIMP-4 sE-selectin, sICAM-1, sVCAM-1, IL-8, IL-10, TNFα, VEGF, Fetuin and haptoglobin measured in neonates was compared to older children with AIS. The gene discussed is TIMP4; the disease is androgen insensitivity syndrome.