Many of the kinases implicated in pathogenesis of HCC, such as kinases in the phosphatidylinositol-3 kinase (PI3K)/AKT and RAF/MEK/ERK pathways, which promote cell survival and cell proliferation, respectively3, are HSP90 clients (http://www.picard.ch/downloads/HSP90interactors.pdf). Here, HSP90AA1 is linked to hepatocellular carcinoma.