When scaled to 1 mmol/L lower LDL cholesterol, the risk for type 2 diabetes based on HMGCR variants13 was an OR of 1·39 (95% CI 1·12 to 1·73), similar to the corresponding scaled estimate for this PCSK9 GS (1·29, 1·11 to 1·50), and similar to an estimate based on SNPs affecting LDL cholesterol selected from throughout the genome (1·27, 1·14 to 1·41).5 This evidence concerns the gene PCSK9 and type 2 diabetes mellitus.