Exploring the PCSK9 associations with incident (appendix) or prevalent (appendix) type 2 diabetes separately showed directional concordance of this effect (incident type 2 diabetes OR 1·15, 0·76 to 1·72; prevalent type 2 diabetes OR 1·26, 0·88 to 1·80). The gene discussed is PCSK9; the disease is type 2 diabetes mellitus.