The HPW[F/L] motif is involved in binding of MEK1 (and other MAPKK dual-specificity kinases) to TRIB pseudokinases 46, 47, 48, whereas the DQXVP[D/E] motif is intimately involved in COP1 binding in all TRIB proteins 49, 50 and required to drive tumorigenesis in leukemia models [51]. The gene discussed is RIBC2; the disease is leukemia.