MYC and cancer: Interestingly, the human TRIB1 gene is located at the same chromosomal locus (8q24.13) as the MYC oncogene and, therefore, MYC (and potentially TRIB1) cancer susceptibility genes are co-amplified in a significant percentage of human tumours, where the 8q24 amplicon is the most commonly amplified region across multiple cancer types [60].