The hypothesis that TRIB1 and PML/RARA cooperate has been tested and, while they do not cooperate to drive a shorter latency leukemia in vivo, TRIB1 and PML/RARA have functionally redundant inhibitory effects on C/EBPα, which also impacts responses [72] to therapeutic All-Trans Retinoic Acid (ATRA, Figure 5). This evidence concerns the gene RARA and leukemia.