Overall, CHI resolved in 15 (71%) children in this cohort at age 3.1 (0.2, 13.0) years with age appropriate fasts in hospital (16–20 h) demonstrating absence of hypoglycaemia, suppressed insulin secretion and robust ketotic responses (Additional file 1: Figure S1 and Additional file 2: Figure S2) supported by satisfactory home glucose monitoring. The gene discussed is INS; the disease is Hypoglycemia.